CD40LG and infection: In comparison with asymptomatic contacts, harboring high counts of NK cells and an early and transient increase of IgA and IgM, and less of IgG, patients with severe infection have shown a marked increase in monocytes, high levels of IgA, and persistent IgG, synthesized relatively late in comparison with patients with a mild infection, in which a moderate monocyte growth and different dynamics of Ab synthesis were reported [144].