All the genes identified to activate the tumor microenvironment pathway were highly upregulated at day 93 PI except secreted phosphoprotein 1 (SPP1), Indoleamine 2,3-dioxygenase 1 (IDO1), UBD and CD274, which were also highly upregulated at day 45 PI (Figure 5B). Here, UBD is linked to neoplasm.