As the focus of this study was to construct a systematic obesity-relevant metabolic network, we first checked the child’s clinical and biological parameters (leptin, OGTT insulin AUC, adiponectin, FFA, TNF-α, FPG, and total cholesterol) that are thought to be related to a change in BMI. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.