IGHE and allergic disease: Studies conducted in an animal model of ovalbumin (OVA) sensitization in the neonatal stage with a previous treatment period with Bifidobacterium strains have demonstrated their potential to alleviate the risk of IgE-mediated allergies in adulthood, by exhibiting a minor increase in serum IgE levels induced by intraperitoneal-OVA challenge in the adult period and significantly higher IL-10 levels than in the control group [167].