HGBCL comprise two different groups of patients: HGBCL-NOS (encompassing cases that either have features intermediate between DLBCL and Burkitt Lymphoma or appear blastoid) and “double-hit/triple hit” HGBCL (HGBCL-DH/TH), which includes cases presenting with MYC and BCL2 and/or BCL6 rearrangements [1]. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.