The compilation of TCGA data from 8,897 cases from BC patients identified 21,058 mutated genes, and the top 10 mutated genes are TP53 (4%), PIK3CA (3.8%), TTN (2.73%), MUC4 (2.21%), MUC16 (1.69%), CDH1 (1.67%), GATA3 (1.58%), MUC2 (1.28%), KMT2C (1.14%) and MAP3K1 (1.02%). This evidence concerns the gene TP53 and breast cancer.