HMOX1 and Shock: Inhibition of HO-1 by using specific HO inhibitors, such as zinc protoporphyrin (ZnPP) or tin protoporphyrin (SnPP), deteriorates the extent of diseases involving the above-mentioned stress stimuli, such as graft rejection [12], ischemia-reperfusion injury [13], cisplatin nephrotoxicity [14], and endotoxin-induced septic shock [15].