TYK2 and COVID-19: In the case of TYK2 gene in chr19 (rs74956615), we observed a compatible point effect, direction and statistical significance for susceptibility (OR = 1.70 (1.13–2.55), p-value = 0.011), COVID-19 fatal outcome (OR = 4.96 (2.02–12.20), p-value = 4.85 × 10−4), an improvement in the meta-analysis (EUR, OR = 1.11 (1.04–1.19), p-value = 1.63 × 10−3; All, OR = 1.11 (1.04–1.19), p-value = 9.92 × 10−4, Supplementary Table S2) and confirmation in the linear mixed models (p-value = 5.5 × 10−4, Supplementary Table S3).