Unlike soluble sPD-L1, sPD-L2 was significantly associated with BCRFS and PC progression (p < 0.05) as other soluble factors (such as sCD28, sCD80, sCTLA4, sHVEM, sIDO, sGITR, sPDCD1). The gene discussed is SPDL1; the disease is pachyonychia congenita.