CAPZB and hyperthyroidism: Genetically predicted hyperthyroidism, despite not reaching statistical significance, showed a significant association with SBP for an SNP in gene CAPZB (chromosome 1 p36.13, rs12138950) that is in high linkage disequilibrium (LD, r2 > 0.9) with an SNP among those used in the TSH instrumental variables (rs10917469).