LRP1 and vitamin A deficiency: Wassef et al. highlight a particular role of LRP1 in mediating the uptake of β-carotene through the placenta and show its activation in response to chronic changes in the vitamin A content in the maternal diet, both in terms of supplementation with β-carotene (which determines decreased transcription of LRP1) and in the case of mild vitamin A deficiency (which induces the uptake of β-carotene) [16].