Subsequently, following transduction of these cells with a MYCN overexpression construct and injection into nude mice, it was shown that in most instances NB develop that recapitulate much of the molecular and cellular phenotype of mouse and human NBs, including CNAs syntenic as those observed in human e.g., 17q gain, 2p gain and 1p36 deletion. The gene discussed is MYCN; the disease is Nijmegen breakage syndrome.