Finally, we also noted that mutant ALK upregulates RET and RET-driven sympathetic neuronal markers of the cholinergic lineage [129] which is intriguing in the light of the recent finding that malignant cells enriched in high-risk NB resemble a subtype of TRKB+ cholinergic progenitor population identified in the human post-natal gland [133]. This evidence concerns the gene ALK and neuroblastoma.