Chang et al., Zhou et al., and Zhang et al. demonstrated in a multi-marker approach that in independent association, high neutrophilia (>7 × 103/mm3), lymphopenia (<0.8 × 103/mm3), significantly decreased CD4+ and CD8+ counts, elevated CRP (>47.5 mg/L), and elevated LDH (>593 U/L) were significant predictors of mortality, with odd ratios of 6.4 for neutrophils, 5.8 for CRP, and 4.2 for LDH [6,7,8,9,10,11,12,13]. Here, CRP is linked to lymphopenia.