F2 and endothelial dysfunction: By stratifying our ACLD cohort by hepatic dysfunction (i.e., Child stage), as well as for portal pressure (by the diagnostic gold-standard HVPG), we observed marked endothelial dysfunction (i.e., VWF antigen increase) and dysbalanced coagulation state (i.e., D-dimer, prothrombin fragments F1,2 levels) with increasing ACLD severity.