In the OS analysis, the multivariate Cox proportional hazards model revealed that serum AFP > 5 ng/mL (HR, 1.592; 95% CI, 1.135–2.232; p  = 0.007), liver cirrhosis (HR, 2.019; 95% CI, 1.527–2.670; p < 0.001), DM (HR, 2.214; 95% CI, 1.675–2.927; p < 0.001), Child–Pugh grade B (HR, 2.310; 95% CI, 1.431–3.731; p = 0.001), multiple tumors (HR, 1.679; 95% CI, 1.029–2.740; p = 0.038), tumor size >2 cm (HR, 1.523; 95% CI, 1.109–2.094; p = 0.009) and vascular invasion (HR, 1.498; 95% CI, 1.129–1.986; p  = 0.005) were independent risk factors associated with OS (Table 3). Here, AFP is linked to neoplasm.