Coding variants in these genes include the variants p.Gly119Arg (rs141853578) in CFI, p.Arg102Gly (rs2230199) and p.Lys155Gln (rs147859257) in C3, and p.Pro167Ser (rs34882957) in C9, which are associated with an increased risk of AMD. The gene discussed is CFI; the disease is age-related macular degeneration.