Increased HDL levels were previously associated with an increased risk of AMD [33,46], and in this study we show that increased HDL levels are associated with decreased C3, FH, VTN, CRP, FCN3, FI, MASP3, FB, MASP1, C4BPB, C1QA, C8B, C2 and FD and properdin levels. The gene discussed is C8B; the disease is age-related macular degeneration.