Increased HDL levels were previously associated with an increased risk of AMD [33,46], and in this study we show that increased HDL levels are associated with decreased C3, FH, VTN, CRP, FCN3, FI, MASP3, FB, MASP1, C4BPB, C1QA, C8B, C2 and FD and properdin levels. This evidence concerns the gene C3 and age-related macular degeneration.