C3 and age-related macular degeneration: Coding variants in these genes include the variants p.Gly119Arg (rs141853578) in CFI, p.Arg102Gly (rs2230199) and p.Lys155Gln (rs147859257) in C3, and p.Pro167Ser (rs34882957) in C9, which are associated with an increased risk of AMD.