C3 and age-related macular degeneration: Within the complement system loci, there were three variants that had more than 10 suggestive associations with other complement protein peptides: the AMD risk-conferring variant rs12019136 at the C3 locus showed suggestive associations with increased levels of 11 peptides, the protective AMD variant rs148553336 at the CFH locus showed suggestive associations with decreased levels of 14 peptides, and the AMD risk-conferring variant rs181705462 at the C2/CFB/SKIV2L locus showed suggestive associations with increased levels of 11 peptides.