VTN and age-related macular degeneration: In addition, our proteogenomics analyses identified significant associations of genetic variants with levels of complement proteins in plasma, adjusted for AMD status, sex and age: FHR-2 peptide levels were associated with AMD variants at the CFH locus, C4 peptide levels were associated with an AMD variant at the C2/CFB/SKIV2L locus, VTN peptide levels were associated with an AMD variant at the TMEM97/VTN locus, FI peptide levels were associated with AMD variants at the CFI locus and C9 peptide levels were associated with an AMD variant at the C9 locus.