This observation on long-term persistence of neutralizing IgG following natural infection is consistent with studies from a German cohort assessed up to 9 months post-infection [64] and other studies showing persistent viral neutralizing antibody correlated with outcome [65], and even that viral rebound after early clearance is associated with lower induction and lower levels of RBD-specific IgA and IgG antibodies [66]. The gene discussed is CD79A; the disease is infection.