Proteomic analysis of SOX4 and its pathway in U266B1 cells (Figure 5A) showed the downregulation of SOX4 (~45%) but also of protein downstream of the SOX4 such as PTEN, AKT, and PI3K (Figure 5A), consistent with what was observed after direct transfection of MM cells (Figure 3A,B). Here, SOX4 is linked to Miyoshi myopathy.