AKT1 and Miyoshi myopathy: Proteomic analysis of SOX4 and its pathway in U266B1 cells (Figure 5A) showed the downregulation of SOX4 (~45%) but also of protein downstream of the SOX4 such as PTEN, AKT, and PI3K (Figure 5A), consistent with what was observed after direct transfection of MM cells (Figure 3A,B).