SOD1 and amyotrophic lateral sclerosis: ALS may occur in a sporadic form, the most common (90–95% of cases), with no known hereditary component, or in a family-form (5–10% of cases) with a hereditary component, involving altered genes such as TAR DNA Binding Protein (TARDBP or TDP43), Superoxide Dismutase 1 (SOD1), FUS RNA Binding Protein (FUS), and C9orf72-SMCR8 Complex Subunit (C9orf72) [5,6,7,8].