In addition, similar studies showed that curcumin inhibited NLRP3 protein expression, caspase1-p20 activation, and caspase-1 and IL-1β levels in lupus-prone mice, as well as suppressed NLRP3 inflammation and IL-1β level in rats [17,55,60]. The gene discussed is CASP1; the disease is systemic lupus erythematosus.