NFKB1 and neoplasm: A previous study reported that protocatechuic acid, a natural phenolic acid found in numerous diets, including vegetables, fruits, teas, and grains, significantly decreased the expression and production of inflammatory mediators in RAW 264.7 and BV-2 cells stimulated with LPS through NF-κB and MAPKs pathways, and can increase the suppression of tumor cell growth and induce caspase-mediated apoptosis on many types of cancer cells [59].