The molecular mechanisms relate to down-regulation of GPX4 expression, modulation of cellular iron homeostasis [80], the stimulation of intracellular ROS production, the lysosomal degradation of ferritin, regulation of system Xc−/GPX4 axis, Nrf2-ARE pathway inhibition in resistant head and neck cancer cells [81] and the activation of ATF4-CHOP-CHAC1 pathway in Burkitt’s lymphoma [82]. The gene discussed is GPX4; the disease is head and neck cancer.