On the other hand, even if malfunction complications have been drastically reduced with the current continuous-flow machines, the long-term complications of the non-pulsatile flow on the microvascular system are well known and described (i.e., shearing of von Willebrand factor multimers, loss of mucosal integrity from oxidative stress, development of arteriovenous malformations, increased angiogenesis) [30,31,32]. Here, VWF is linked to arteriovenous hemangioma/malformation.