In conclusion, we can affirm that the two most important fibrillar proteins of the ECM of the conjunctival stroma, collagen, and elastin, as well as several constituents involved in elastic fiber assembly are overexpressed in human pterygium; thus, supporting the hypothesis that there is dysregulation in the synthesis and crosslinking of the fibroelastic component, constituting an important pathogenetic mechanism for the development of the disease. This evidence concerns the gene ELN and pterygium.