Different cytokine hubs (e.g., TNFα and the IL-23 – IL-17 axis in psoriatic disease versus IL-6 and TNFα as a central cytokine network in rheumatoid arthritis (RA)) and index condition specific features (e.g., adipocytokines in obesity, inflammaging in elderly, and uremia in chronic kidney disease) may alter the affinity for organ injury, impairment and thus clinical presentation. This evidence concerns the gene TNF and obesity disorder.