Different cytokine hubs (e.g., TNFα and the IL-23 – IL-17 axis in psoriatic disease versus IL-6 and TNFα as a central cytokine network in rheumatoid arthritis (RA)) and index condition specific features (e.g., adipocytokines in obesity, inflammaging in elderly, and uremia in chronic kidney disease) may alter the affinity for organ injury, impairment and thus clinical presentation. The gene discussed is TNF; the disease is Obesity.