Another study shows how the activation of interferon regulatory factor 7 (IRF 7) was induced in pancreatic plasmacytoid dendritic cells (pDCs) in experimental AIP in mice, and that siRNA-mediated suppression of IRF7 expression prevented the development of AIP, leading to a reduction in the accumulation of pDCs in the pancreas and the production of IFN-α and IL-33 [53]. The gene discussed is IL33; the disease is autoimmune pancreatitis.