A recent study using newly designed tetramers to detect human T cells specific for ApoB-derived peptides ApoB3036–3050, possible atherosclerosis-related antigens, has shown that healthy subjects have ApoB-specific Foxp3+ Tregs, and that these Tregs coexpress other CD4 lineage transcription factors, such as ROR-γt, in patients with subclinical cardiovascular disease [88]. This evidence concerns the gene APOB and cardiovascular disorder.