Interestingly, this study also demonstrated that adoptive transfer of wild-type CD4+CD25+ Tregs expressing folate receptor 4 into CD27-deficient Apoe−/− mice reversed the phenotype of atherosclerosis, indicating a causative role of decreased Treg frequency in CD27-deficiency-dependent atherosclerosis progression [53]. This evidence concerns the gene IZUMO1R and atherosclerosis.