The proportion of Foxp3+ Tregs within the splenic CD4+ T cell population was markedly increased in Ldlr−/− mice fed a cholesterol-rich diet, whereas their accumulation in atherosclerotic plaques was impaired in association with decreased expression of their surface molecules related to migratory function, which was prevented by reversal of hypercholesterolemia [77]. The gene discussed is CD4; the disease is familial hypercholesterolemia.