Another study by the same group using a tetramer to detect ApoB978–993-specific T cells has revealed that ApoB-specific T cells in Apoe−/− mice convert from mixed Th17/Treg cells with a regulatory anti-inflammatory transcriptome into proinflammatory Th1/Th17-like cells that secrete inflammatory cytokines, and that these ApoB-specific CD4+ T cells with a predominant Th1/Th17 phenotype were detected in the blood of patients with CAD [89]. This evidence concerns the gene APOB and coronary artery disorder.