IL1B and major depressive disorder: The level of IL-1beta decreases with the use of pharmacotherapy of depression with SSRI drugs [35,37], as well as during the augmentation of pharmacotherapy with electroacupuncture [34] and curcumin [38], and the decrease in the level of IL-1 beta correlates with lower severity of depressive symptoms [39], but this effect is not confirmed in all studies [36,40,41].