In addition, in a neonatal mouse model of sepsis, the use of immunomodulatory agents, including Toll like receptor 4 (TLR4) or TLR7/8 agonists [7], aluminum salt-based adjuvants [9], and Bacille Calmette-Guérin (BCG) [10], have been investigated extensively. This evidence concerns the gene TLR4 and Sepsis.