HLA-DRA and Sepsis: Following sepsis, decreased major histocompatibility complex (MHC) mRNA expressions of class II-related genes have been reported; in one study, mRNA expression of five MHC class II-related genes (CD74, HLA-DRA, HLA-DMB, HLA-DMA, CIITA) were measured by quantitative reverse transcription (qRT)-PCR and monocyte human leukocyte antigen-DR (mHLA-DR) by flow cytometry in septic shock patients [218].