Briefly, alpha-1 antitrypsin is a serine protease inhibitor primarily produced in the liver to protect tissues from damage due to infection and resulting inflammation, where the absence of AAT and/or presence of recurring respiratory exacerbations in these subjects initiates lung tissue damage due to underlying inflammation, leading to COPD-emphysema pathogenesis [1,11]. Here, SERPINA1 is linked to chronic obstructive pulmonary disease.