NOS3 and brain ischemia: Accordingly, in the setting of ACI, evidence from animal models of cerebral ischemia has indicated that circulating omentin: (1) improves the ischemic brain injury by suppressing oxidative stress, apoptotic and postischemic inflammatory cascades, (2) precipitates vasodilation and (3) promotes the postischemic revascularization in the brain by regulating the endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VEGF) signalling pathways [30].