According to the new Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions (LAST) classification, squamous intraepithelial lesions (SIL) are divided into low-grade lesions—LSIL (CIN1 and CIN2 p16 negative lesions) and high-grade lesions—HSIL (CIN2 p16 positive and CIN3 lesions) [6,7]. This evidence concerns the gene CDKN2A and squamous cell intraepithelial neoplasia.