Interestingly, CD8+CD25+ Tregs appear to be increased in women with lupus in comparison to healthy gestation, while CD4+CD25+ Tregs are decreased in lupus pregnancy; the explanation relies on an altered IL-2 profile during pregnancy that is able to activate CD8+ Tregs more potently than CD4+ Tregs, higher levels of CD8+ Tregs subpopulation being necessary to maintain pregnancy [19,22]. Here, CD8A is linked to systemic lupus erythematosus.