Pre-eclampsia stage II matching the third trimester is prompted by increased circulating levels of hypoxia-stimulated factors (soluble fms-like tyrosine kinase-1, sFLT1, and soluble endoglin, sEng), decreased circulating levels of placental inhibitor growth factor (PIGF) and vascular endothelial growth factor (VEGF) together with other predisposing factors such as obesity, pro-inflammatory factors, and angiotensin II type-1 receptor autoantibodies (AT1-AA) [1,6,7,23,32,38]. This evidence concerns the gene VEGFA and obesity due to melanocortin 4 receptor deficiency.