Cardiac-specific expression of wild type but not S153 phosphorylation deficient mutant (S153A) increases β-adrenergic receptor (βAR), a 7-transmembrane GPCR involved in cardiac contractility, leading to protect mice from heart failure induced by chronic pressure overload; conversely, RKIP knockout mice are associated with exacerbation of pressure overload-induced heart failure [58,59]. Here, PEBP1 is linked to heart failure.