The predictive value was kept in within the IPI L+LI and H+HI strata, within the EBER-negative cases (but not in the EBER-positive cases), within MYC translocation positive and negative cases, and within the non-High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (i.e., DLBCL NOS) (but not in the 11 High-grade B-cell lymphomas). The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.