Increased DSBs and reduced clonogenic potential of imatinib-refractory CML cell lines and primary samples, including under hypoxic conditions mimicking the bone marrow microenvironment. Eliminated quiescent cells in an inducible mouse model of chronic-phase CML. Reduced leukemic burden up to 10-fold in a BCR-ABL1+ leukemia xenograft model. Here, BCR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.