However, for some of the genes, clinical relevance has been shown in other tumor entities, e.g., in prostate cancer, an overexpression of TMPRSS2 has been correlated to cancer cell invasion and metastasis [46], and a high IL1R2 expression has been linked to a decreased overall survival and relapse-free survival in breast cancer patients [47]. The gene discussed is TMPRSS2; the disease is prostate cancer.