This investigation revealed genes described in the literature, which play roles in esophageal cancer and other types of cancer as TOX4 and APOBEC3 gene cluster related to genomic instability, PRMT5, AJUBA promoting tumor migration and invasion, ZNF219, CEBPE and SAL2 genes associated to tumor progression and aggressiveness, respectively. This evidence concerns the gene TOX4 and esophageal cancer.