Soluble blood biomarkers that were frequently investigated were LDH, leukocyte counts including lymphocytes, neutrophils, eosinophils and the ratio between these cytology markers, myeloid-derived suppressor cells (MDSCs and subset monocytic MDSCs (moMDSCs)), natural killer (NK) cells, systemic inflammation markers such as cytokines and S100, and circulating tumor cells (CTCs). The gene discussed is S100B; the disease is neoplasm.