In 2005, Demaria et al. [54] have in particular showed that when a poorly immunogenic murine model of metastatic BC (4T1 cells) was implanted subcutaneously in mice, the combination of 9H10 (an anti- CTLA-4 antibody) and RT was the only regimen which allowed an improvement of survival and especially CTL-mediated inhibition of the formation of lung metastases. The gene discussed is CTLA4; the disease is breast cancer.