In summary, although the accurate pathophysiological mechanisms of the onset and progression of sarcopenia are complex and still not fully clarified, they could include a state of low-degree systemic inflammation characterized by an increasing level of pro-inflammatory cytokines, including TNF-α, IL-1, IL-6, and a variable level of anti-inflammatory cytokines, such as IL-10 [11,13,57,58]. The gene discussed is TNF; the disease is sarcopenia.