For instance, Garg et al. described genetic changes in 161 cancer driver genes in 14 GAS cases using next-generation sequencing, identifying gene alterations in TP53 (50%), MSH6 (43%), CDKN2A/B (36%), POLE (36%), SLX4 (36%), ARID1A (29%), STK11 (29%), BRCA2 (21%), and MSH2 (21%) [77]. The gene discussed is CDKN2A; the disease is flatulence.