PTEN and flatulence: According to Hodgeson et al., TP53 (46%), KRAS (36%), and PIK3CA (18%) were the most often altered genes in 11 GAS cases [78], whereas Lu et al. found that TP53 (53%), STK11 (33%), CDKN2A (27%), ARID1A (20%), and PTEN (20%) were the most frequently mutated genes in 15 cases of GAS, with frequent ERBB2 amplification (13%) [76], and primarily affected the cell cycle and PI3K/AKT signaling pathways.