Although the characteristic genetic abnormalities in cervical endometrioid adenocarcinoma remain unknown, Jenkins et al. recently reported eight HPV-negative cases of cervical endometrioid adenocarcinoma harboring various somatic gene mutations, including PIK3CA (50%), PTEN (50%), CTNNB1 (3/8%), FBXW7 (25%), KRAS (1/8%), AKT1 (1/8%), and MSI-H (1/8 %) [44]. This evidence concerns the gene AKT1 and cervical endometrioid adenocarcinoma.