We previously evaluated 14 ASC samples using targeted DNA sequencing and identified genetic alterations in PIK3CA (2/14%), TP53 (1/14%), and KRAS (1/14%), HER2 amplification, and PTEN copy number loss [49], which partly resembles the genetic profile of HPV-positive SqCC or adenocarcinoma. The gene discussed is PTEN; the disease is adenocarcinoma.