PIK3CA and adenocarcinoma: No cases had PIK3CA or PTEN alterations, unlike usual-type adenocarcinoma, and none had microsatellite instability; however, some chromosomal structural abnormalities have been observed in mesonephric carcinomas, including copy number gains in 1q, the loss of 1p, and the gain of chromosomes 10 and 12 [80].