Liu et al. evaluated the presence of Tregs and cytotoxic T lymphocytes (CTLs) by IHC in 1270 cases of invasive BC to assess their association with patient survival, histopathologic features, and molecular subtypes, and found that high infiltration of Foxp3+ Tregs in the tumor bed was associated with HER2 overexpression, decreased overall survival (OS), and progression-free survival (PFS) [32]. This evidence concerns the gene FOXP3 and breast cancer.