Another interesting observation from RAP1A was the disparity in methylation between DMRs in NDMM subgroups and MM cell lines, such that DMR-5 was not differentially methylated in NDMM subgroups (MDM = −0.05, p = 0.593), but was hypomethylated in MM cell lines (MDM = −0.21, p = 0.005). This evidence concerns the gene RAP1A and Miyoshi myopathy.