By MutSig analyses, we found a significant overrepresentation of non-silent somatic mutations in 14 cancer-related genes, namely TP53, THY1, CYBA, THAP1, MYOZ3, RPS5, IL9R, CNPY4, FCGR3A, RAB40A, RNASEH1, CDKN2A, ACAT1, and CLEC11A. The gene discussed is CDKN2A; the disease is cancer.