Also connexin-43 (GJA1 gene), a gap junction protein, once internalized is degraded by autophagy after SQSTM1/p62 binding and delivery to autophagosome [150] and, interestingly, connexin-43 has been observed to be downregulated in breast and prostate cancers [151,152]. The gene discussed is GJA1; the disease is Familial prostate cancer.