Clearly, the activation of secretory autophagy in tumor and stromal cells results in the release in the extracellular space of a number of factors, including inflammatory cytokines and chemokines (e.g., interleukin 1β, CXCL8, LIF), thus impacting on the tumor microenvironment [163,164,165]. The gene discussed is CXCL8; the disease is neoplasm.