Together, these findings support the view that TRIB interactomes may harbor a uniform component (overlap between for example HEK293T cells and MCF7 cells) as well as a flexible component that depends on cell type (e.g., hepatocyte vs. HEK293T cells vs. MCF7 breast cancer cells) or cellular status (e.g., proliferative status, metabolic status). Here, RIBC2 is linked to breast cancer.