TRIB1 and Familial prostate cancer: For example, TRIB1 upregulation is significantly associated with metastasis and poor prognosis in prostate cancer [24], it has been shown that TRIB1 mediates radioresistance in glioma cells by an HDAC1-dependent pathway [25] and high levels of TRIB1 are associated with poor breast cancer survival through the regulation of PI3K-NFκB pathway [26].