This study was an outcome of early studies started almost 20 years ago, using targeted DNA vaccines technology and autoantibodies generated using this approach, we reported that CXCL10 and perhaps CXCL9, but not CXCL11 are associated with the induction of IFNghigh CD4+ effector Th1 cells, and therefore targeted neutralization of CXCL10 may restrain T cell-mediated autoimmunity [192,193]. Here, CXCL10 is linked to Autoimmunity.