CXCR1 and breast carcinoma: Breast cancer is among the most relevant human diseases for the blockade of the CXCL8-CXCR1/2 interaction since CXCL8 is up-regulated in breast cancer patients is associated with poor prognosis [148,149], and CXCL8 drives tumor stemness and angiogenesis [146,150,151,152].