CCR4 and cancer: In human cancers, major target diseases are several solid tumors, B-cell lymphomas, T-cells lymphomas, and leukemia in which not only CCR4 is highly expressed within the tumor microenvironment by Tregs, NK cells, and tumor cells, but mostly in those that poor prognosis has been associated with high expression of CCR4 on these cells [251,252,260,261,262,263].