The importance of CXCR3-ligands in the recruitment of tumor-infiltrating lymphocytes (TILs) to the TME had also been demonstrated in several human cancers in which CXCR3+ TILs were abundant and high levels of CXCL9 and CXCL10 were secreted by stromal cells [206,207]. This evidence concerns the gene CXCL9 and cancer.