STAT3 and breast cancer: Indeed, in breast cancer cell lines MDA-MD-231 and MDA-MD-468 (TNBC cells), NS8593 suppresses TRPM7 Mg2+-dependent currents [140], increasing the apoptotic and antiproliferative effects induced by TRAIL via a decrease in c-FLIP as well as suppressing the phosphorylation of STAT3, respectively [109,111].