TNFSF10 and breast carcinoma: More recently, in other breast cancer cells, MDA-MB-231, inhibition of the channel with NS8593, increases the apoptotic and antiproliferative effects induced by TRAIL, while inhibition of kinase activity with TG100-115 has no effect, suggesting that TRPM7 mediates TRAIL-induced apoptosis via calcium ion fluxes [109].